منابع مشابه
Binding Energy and Enzymatic Catalysis
For nearly 100 years, the extraordinary catalytic power of enzymes has fascinated biochemists (1). In a recent article in this Journal, Splittgerber (2) analyzed several ofthe factors by which enzymes are thought to effect catalysis, including proximity and orientation effects, substrate strain, acidbase catalysis, and nucleophilic catalysis. Here we will discuss the fundamental role that the f...
متن کاملGeneric features of quinone-binding sites.
Introduction: generic features of quinone-binding sites (Q sites) Quinones form a central link between protein complexes in most types of electron-transfer chain. More than 50 distinct types of Q site associated with respiratory and photosynthetic electron-transfer complexes have been identified to date. Most involve rather loose and dynamic binding of quinone, and for these Q sites inhibitory ...
متن کاملHerbicide/Quinone Binding Interactions in Photosystem II
Many inhibitors prevent the oxidation o f the primary electron-accepting quinone (QA) by the secondary quinone (QB) in photosystem II by displacem ent o f Q B from its binding site. On the other hand, plastoquinone-1 and 6-azido-5-decyl-2,3-dim ethoxy-/?-benzoquinone displace herbicides. Binding studies show the herbicide/quinone interaction to be (apparently) competitive. The herbicide binding...
متن کاملQuinone binding and reduction by respiratory complex I.
Complex I (NADH:ubiquinone oxidoreductase) has a central function in oxidative phosphorylation and hence for efficient ATP production in most prokaryotic and eukaryotic cells. This huge membrane protein complex transfers electrons from NADH to ubiquinone and couples this exergonic redox reaction to endergonic proton pumping across bioenergetic membranes. Although quinone reduction seems to be c...
متن کاملBinding sites of lipophilic quinone and quinone analogue inhibitors in the cytochrome b6f complex of oxygenic photosynthesis.
The main structural features of the cytochrome b6f complex, solved to 3.0-3.1 A (1 A = 10(-10) m) in the cyanobacterium Mastigocladus laminosus and the green alga Chlamydomonas reinhardtii are discussed. The discussion is focused on the binding sites of plastoquinone and quinone analogue inhibitors discerned in the structure. These sites mark the pathway(s) of quinone translocation across the c...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Bioenergetics
سال: 2010
ISSN: 0005-2728
DOI: 10.1016/j.bbabio.2010.10.021